The rapid emergence and exploding usage of online social networking forums, which are frequented by millions, present clinicians with new ethical and professional challenges. Particularly among a younger generation of physicians and patients, the use of online social networking forums has become widespread. In this article, we discuss ethical challenges facing the patient–doctor relationship as a result of the growing use of online social networking forums. We draw upon one heavily used and highly trafficked forum, Facebook, to illustrate the elements (...) of these online environments and the ethical challenges peculiar to their novel form of exchange. Finally, we present guidelines for clinicians to negotiate responsibly and professionally their possible uses of these social forums. (shrink)

Claims about ‘the meaning of life’ have tended to be made and discussed in conjunction with bold metaphysical and theological affirmations. For life to have meaning, there must be a comprehensive divine plan to give it meaning, or there must be an intelligible cosmic process with a ‘telos’ that a man needs to know if his life is to be meaningfully orientated. Or, it is thought to be a condition of the meaningfulness of life, that values should be ultimately ‘conserved’ (...) in some way, that no evil should be unredeemable and irrational. And it may be claimed that if death were to end our experience, meaninglessness would triumph. (shrink)

En su inicio, el empirismo ha querido ser, en una época de profundas dudas y cambio:como ha sido la Época Moderna, una honesta crítica a los argumentos presentados por el racionalismo, según el cual se debía poner el fundamento del conocimiento en algunas verdade: innatas. La propuesta del empirismo hizo descansair esta esperanza en los datos fidedignos de la impresiones o experiencias sensofiales. En este artículo se analiza la concepción de idea que empleaba John Locke y sus argumentos para desautorizar, (...) una tras otra, las razones del innatismo. No obstante, en el ámbito moral, sigue manteniendo una luz de la naturaleza, ínsita em los hombres, que es recta norma para la razón., para quienes buscan conocetrla. De todos modos, que da establecido, con el empirismo de Locke, que explicar el conocimiento de una cosa implica explicar el origen que el hombre tiene de esse conocimiento, revalidando el valor de la investigación humana y de la historicidad del conocimiento. (shrink)

A photoaffinity analog of cGMP has been used to biochemically identify a new ligand-binding subunit of the retinal rod cGMP-activated ion channel, as well as amino acids in contact with cGMP in the original subunit. Covalent tethering of this probe to channels in excised menbrane patches has revealed a functional heteogeneity in the ligand-binding sites that may arise from the two biochemically identified subunits.